Copenhagen, Denmark: Ashkenazi Jewish women are known to have a predisposition to the inherited breast cancers BRCA1 and BRCA2, but currently genetic testing in this group is limited to women affected by breast and ovarian cancers and those who are unaffected but have a family history of the disease. Ms Sari Lieberman, a genetic counsellor […]
Category: Genetics
Balancing rights and responsibilities in insurers’ access to genetic test results
Copenhagen, Denmark: Genetic testing is widely used across the developed world in order to diagnose and predict disease. However, along with its usefulness comes concern about how others, such as employers and insurers, can have access to and use its results. This in turn leads to the risk that individuals may avoid medically recommended genetic testing, […]
Loss of Y chromosome in blood cells is associated with developing Alzheimer’s disease: new research could lead to a simple test to identify those at risk
Barcelona, Spain: Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease (AD), and this is in addition to an increased risk of death from other causes, including many cancers, researchers told the annual conference of the European Society of Human Genetics. The paper […]
Discovery of new disease gene will lead to better screening for severe paediatric heart disease
Barcelona, Spain: Cardiomyopathy, or a deterioration of the ability of the heart muscle to contract, generally leads to progressive heart failure. It is frequently inherited, and, because approximately 40% of children born with it are likely to die within five years of diagnosis, being able to identify its genetic basis is particularly important. Now, an […]
Dietary experiments in mice point the way to early detection of cancer development in humans
Barcelona, Spain: Colorectal cancer is the second most common cause of cancer-related deaths in the Western world, mainly because it is usually diagnosed too late. Finding ways to identify those people who are at increased risk of developing colon cancer is therefore crucial, a researcher told the annual conference of the European Society of Human Genetics. […]
How does obesity cause disease in organs distant from those where fat accumulates? New genetic evidence points the way
Barcelona, Spain: Obesity is on the rise throughout the world, and in some developed countries two-third of the adult population is either overweight or obese. This brings with it an increased risk of serious conditions such as heart disease, stroke, cancer and osteoarthritis. Many of these conditions do not appear to affect the parts of […]
Drug combination improves progression-free survival in melanoma patients regardless of genetic status, age and spread of disease
Vienna, Austria: Patients with advanced melanoma skin cancer survive for longer without their disease progressing if they have been treated with a combination of two drugs, nivolumab and ipilimumab, than with either of these drugs alone. New results show that these patients also do better regardless of their age, stage of disease and whether or […]
Discovery of differences between tumours of younger and older colorectal cancer patients may lead to better treatments
Vienna, Austria: Colorectal cancer (CRC) is on the rise among younger patients. Although some of the younger-onset cases can be explained by hereditary factors, the majority arise spontaneously. Researchers have now found that tumours in younger colorectal cancer patients may be molecularly distinct from those of older patients, and that these differences are related to […]
Genetic screening of brain metastases could reveal new targets for treatment
Vienna, Austria: Unravelling the genetic sequences of cancer that has spread to the brain could offer unexpected targets for effective treatment, according to new research presented to the 2015 European Cancer Congress [1] and published simultaneously in Cancer Discovery [2]. Researchers told the Congress that they found that the original, or primary, cancer in a […]
Discovery of significant genetic differences between breast cancers that relapse and those that do not will lead to better treatment
Vienna, Austria: Although most patients with breast cancer are cured after treatment, in about one in five the cancer will recur, returning either to the same place as the original tumour or spreading to other parts of the body (metastasis). Now, researchers have taken an important step towards understanding why some primary breast cancers return […]