A small patient trial also suggests CPAP may be more effective than a weight-loss drug in tackling clogged arteries.
Milan, Italy: People suffering with obstructive sleep apnoea (OSA) can reduce their risk of dying from cardiovascular disease if they use a continuous positive airway pressure (CPAP) machine at night, according to research presented at the European Respiratory Society International Congress in Milan, Italy .
CPAP may also work better than a weight loss drug in reducing the build-up of plaque in the arteries around the heart, according to a pilot study also presented at the European Respiratory Society International Congress .
People with OSA often snore loudly, their breathing starts and stops during the night, and they may wake up several times. This can lower the amount of oxygen in the blood and cause tiredness. It can also increase the risk of high blood pressure, stroke, heart disease and type 2 diabetes.
CPAP machines are offered to people with OSA to help them sleep better. They work by blowing air through a face mask throughout the night to prevent the user’s airways from closing. However, research on the effects of CPAP on cardiovascular disease has produced mixed results.
The heart disease study was presented by Dr Jordi de Batlle from Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain. He and his colleagues tracked down all 3,638 OSA patients living in Catalonia who had chosen to stop using CPAP in 2011. They compared these to a similar group of 3,638 OSA patients who continued to use CPAP until at least 2015 or until death.
When they compared the two groups, they found that those who continued to use CPAP had a 40% lower risk of dying by any cause, a 36% lower risk of dying from cardiovascular disease and an 18% lower risk of being hospitalised with cardiovascular disease.
Dr de Batlle said: “Our results suggest that CPAP treatment can help most OSA patients by preventing cardiovascular problems such as heart disease and stroke. This is a plus, as CPAP treatment already helps most OSA patients by reducing sleepiness and improving their quality of life. Based on these findings, we should encourage people with OSA to keep using their CPAP machines.”
The pilot study was presented by Dr Cliona O’Donnell, a specialist registrar in respiratory medicine at St. Vincent’s University Hospital and University College Dublin, Ireland. She and her colleagues conducted a study with 30 patients suffering from OSA who underwent a computerised tomography (CT) coronary angiogram to assess any signs of narrowing in the blood vessels that supply the heart.
The patients were then randomly assigned to 24 weeks of treatment either using a CPAP machine at night, or injections with weight loss drug liraglutide, or both together.
Patients who showed signs of coronary artery disease in their first scan underwent a repeat scan at the end of the 24 weeks of treatment. Researchers used an artificial intelligence program to analyse the patients’ scans.
The patients who were treated with CPAP and those treated with CPAP and weight loss injections experienced reductions in the plaque build-up in their arteries and a reduction of inflammation in their aorta (the main artery that carries blood from the heart to the rest of the body). Patients who were treated with weight loss injections only did not experience these effects.
Dr O’Donnell said: “Continuous positive airway pressure works by keeping patients’ airways open while they sleep. This stops fluctuations in oxygen levels in the blood that can exacerbate cardiovascular disease.
“Although this is a pilot study, meaning we cannot draw firm conclusions, we found improvements in some early signs of cardiovascular disease with CPAP treatment. This should now be further evaluated in larger studies.”
Professor Sophia Schiza, who is secretary of the European Respiratory Society’s group assembly on sleep-disordered breathing and was not involved in the research, says: “We know that people with obstructive sleep apnoea are at a higher risk of cardiovascular problems, but there are conflicting data on the effects of CPAP on reducing this risk. However, research using real world data is showing that CPAP adherence is one of the key predictors for reducing cardiovascular risk and for better outcomes in general. Here we have two studies: one large study showing that CPAP could help lower the risk of developing or dying from cardiovascular disease in people suffering with OSA and another small study suggesting that CPAP could be more beneficial than weight-loss therapy for people suffering from OSA.
“OSA is an extremely common disease, with consequences for people’s daytime functioning and the health of their hearts, blood vessels and metabolism. One of the treatment options is CPAP, and the more the patients use CPAP every night, the greater the reduction in cardiovascular illness and death. Therefore, there is a need for individualised treatment plans, patient engagement, educational activities and close treatment follow-up in order to increase adherence to long-term treatment and improve outcomes for patients.”
Notes to editors
 Abstract no: OA3290 “Impact of CPAP treatment on cardiovascular outcomes: a Catalan nationwide database analysis”, by Jordi de Batlle et al; Presented in session, “Positive airway pressure for sleep-disordered breathing: adherence and outcomes” at 15:45-17:00 CEST on Monday 11 September 2023. https://k4.ersnet.org/prod/v2/Front/Program/Session?e=379&session=16589
Funding: This study was supported by Instituto de Salud Carlos III (ISCIII) through the project “PI18/00502”, co-funded by ERDF, “A way to make Europe”; Spanish Respiratory Society (SEPAR); Sociedad Española de Sueño (SES); Societat Catalana de Pneumologia (SOCAP) – Beca Esteve Teijin; Associació Lleidatana de Respiratori (ALLER); and ResMed Foundation. I also must personally acknowledge my contracts with the Catalan Departament de Salut (PERIS 2016: SLT002/16/00364) and Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP19/00108), co-funded by the European Social Fund (ESF), “Investing in your future”.
 Abstract no: OA3287 “The effect of CPAP therapy on coronary artery plaque volume in obstructive sleep apnoea: data from a proof-of-concept study”, by Cliona O’Donnell et al; Presented in session, “Positive airway pressure for sleep-disordered breathing: adherence and outcomes” at 15:45-17:00 CEST on Monday 11 September 2023. https://k4.ersnet.org/prod/v2/Front/Program/Session?e=379&session=16589
Funding: The Health Research Board, Ireland